Ganga Jamuna is a dacoit drama taking off from Hollywood Gangster films like Manhattan Melodrama (1934), and pioneered a widely copied action formula of two brothers on opposite sides of the law, most notably in Deewaar (1975). The most significant departure from the Hollywood stories is that the two protagonists here are brothers rather than buddies like in Manhattan Melodrama or kids who have grown up in the same block like Angels with Dirty Faces (1938) and what's more real life brothers Dilip Kumar and Nasir Khan play the protagonists! And like most of the films of this type, the focus and sympathy is totally on the good man who is forced by circumstances to turn bad. But having taken up a life of crime, his redemption, in spite of all that he has gone through, comes only with his death.

Directed by New Theatres old-timer Nitin Bose (though supposedly ghost-directed by Dilip Kumar), Ganga Jamuna is a well-structured and briskly paced film and was notable of the use of Bhojpuri dialect, which helps make the film refreshingly real and gives it a proper locale and geography. The performances by lead artistes Dilip Kumar and Vyjayantimala are faultless and full marks to the latter who in spite of her South Indian upbringing speaks the Bhojpuri dialect flawlessly. While Vyjayantimala deservedly won the Filmfare Award that year for Best Actress, shockingly Dilip Kumar lost out to Raj Kapoor for the Best Actor award, which the latter won for his production Jis Desh Mein Ganga Behti Hai (1960).

The lyrics of the film also make use of the Bhojpuri flavour and Naushad's earthy music naturally does its work to enhance the film without thrusting itself too obtrusively on the attention of the audience. Nain Lad Gayin re (sung by Mohd. Rafi), Do Hanson ka Joda and Dhoono Dhoondo re Saajna (both sung by Lata Mangeshkar) are particularly well tuned and were popular hits.

Ganga Jamuna is one of the few Indian films that enjoy legendary cult status and runs to packed houses even when released today.